Tamoxifen is used to treat some types of breast cancer in men and women. Tamoxifen is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Tamoxifen is a drug used to treat breast cancer. It’s a type of hormone therapy, also known as endocrine therapy. It can be used by both premenopausal women (women who still have periods) and postmenopausal women (women whose periods have stopped). It can also be taken by men who have breast cancer. 2. How tamoxifen works. Tamoxifen is an antiestrogen drug used in the treatment of breast cancer. It blocks the activity of estrogen, helping to stop the growth of some tumors. TAMOXIFEN (ta MOX i fen) prevents and treats breast cancer. It works by blocking the hormone estrogen in breast tissue, which prevents breast cancer cells from spreading or growing. Tamoxifen and raloxifene have been shown to reduce the risk of breast cancer for some women. Learn more about these medications and their possible side effects. Overview: Tamoxifen is commonly used to treat certain types of breast cancer. It is also used to lower your risk of invasive breast cancer and keep some breast cancers from coming back. It blocks. Tamoxifen (Nolvadex), a hormone therapy drug, is used to treat hormone-receptor positive breast cancers. Tamoxifen is a nonsteroidal SERM of the triphenylethylene family and was structurally derived from diethylstilbestrol -like estrogens and antiestrogens such as chlorotrianisene and ethamoxytriphetol. [103][104][105][106] Initially, clomifene was synthesized, and tamoxifen was developed subsequently. [103][105][106] Tamoxifen is closely related. Tamoxifen is a prescription medicine that is used to treat breast cancer in men and women. It is in a class known as a selective estrogen receptor modulator (SERM) and is used to treat hormone receptor-positive breast cancer. Tamoxifen (brand names: Nolvadex, Soltamox) is a medicine that blocks the effects of the hormone estrogen (called a selective estrogen receptor modulator, or SERM). Tamoxifen is a first choice among doctors for treating women who have not yet gone through menopause.